Every study we read on this question

Trials in people (7)

• 13-week trial in 40 inactive older adults: rapamycin did not clearly improve chair stands
  Randomized trial202640 peopleNo difference
• 16-week trials in 1,676 older adults: RTB101 helped in one trial, not the other
  Randomized trial20211,676 peopleMixed
• 6-week trial in 264 older adults: low-dose mTOR-blocker mix lowered infections for a year
  Randomized trial2018264 peoplePoints to benefit
• 48-week trial in healthy adults: weekly rapamycin did not clearly change belly fat
  Randomized trial2025No difference
• 8-week trial of rapamycin in 25 older adults: no clear change in thinking tests
  Randomized trial201825 peopleNo difference
• Trial in 36 adults with sun-aged skin: rapamycin cream lowered an aged-cell marker
  Randomized trial201936 peoplePoints to benefit
• Trial in older volunteers: RAD001, a rapamycin-like drug, raised flu shot response about 20%
  Randomized trial2014Points to benefit

Population studies (1)

• Survey of 333 adults who used rapamycin off-label and 172 who never did
  Population study: one-time survey2023505 peopleNo direction

Animal and cell (2)

• In mice with an aged immune system, rapamycin eased aging markers and improved immunity
  Animal study2021Points to benefit
• In mice, rapamycin started at 600 days of age extended lifespan
  Animal study2009Points to benefit

Reviews (5)

• In animals, pooled review of 167 papers: rapamycin extended lifespan, metformin did not
  Pooled review (meta-analysis)2025Points to benefit
• Review of 19 human studies: rapamycin-type drugs improved some aging measures, not others
  Systematic review2024Mixed
• In mice bred for Alzheimer's, pooled review of 13 studies: rapamycin improved maze performance
  Pooled review (meta-analysis)2024Points to benefit
• In mice, pooled review of 23 infection studies: rapamycin raised survival after infection
  Pooled review (meta-analysis)2023Points to benefit
• In mice, pooled review of 29 studies: rapamycin lowered death risk, more in females
  Pooled review (meta-analysis)2017Points to benefit

Opinion (1)

• In mice, review of rapamycin studies: evidence strong for lifespan and age-related conditions
  Opinion or narrative review2021Points to benefit