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Trial plan, no results yet

Plan for a 3-month trial of berberine in 240 adults with slow-onset autoimmune diabetes

Zhang and colleagues · Frontiers in endocrinology · 2022

Original title: Effects of Berberine Plus Inulin on Diabetes Care in Patients With Latent Autoimmune Diabetes in Adults: Protocol for a Randomized Controlled Trial.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

No direction

Trial plan only. No results. The main planned measure is change in HbA1c.

The study at a glance

Type of study
Trial plan, no results yet
Who or what was studied
Planned: 240 adults with slow-onset autoimmune diabetes already on insulin
What was tested
Planned: berberine, berberine plus inulin fiber, inulin, or placebo for 3 months
How long
13 weeks
Trial registration
NCT04698330
Who has a stake
No stake declared
No competing interests declared.
Journal
Frontiers in endocrinology, 2022
Source
PubMed record 35784546. This page is based on the abstract only.

How much this study counts

  • •A trial plan. It has no results yet.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

This paper is not on the ladder. It is a trial plan, no results yet, and reviews and opinion pieces discuss studies that are already counted on the steps below.

↑ Stronger evidence

  1. Trials in people: weight and blood sugar

    7

    7 benefit

  2. Trials in people: other measures

    7

    5 benefit, 1 mixed, 1 no difference

  3. Trials in people: lab tests or safety

    2

    1 benefit, 1 no difference

  4. Population studies

    2

    2 benefit

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does berberine help with weight loss and blood sugar?”

Lowers blood sugar in diabetes; weight unclear.

Confidence: low. Based on 28 on-topic papers.

Read the full answer
  • On the watch list: Berberine plus inulin in autoimmune diabetes.

Other trials in people on this question

See all 28 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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