Every study we read on this question

Trials in people (17)

• A 12-week berberine plus cinnamon trial in type 2 diabetes found lower blood sugar
  Randomized trial2025Points to benefit
• A 12-week HTD1801 trial in 113 adults with type 2 diabetes: lower blood sugar
  Randomized trial2025113 peoplePoints to benefit
• A 12-week berberine trial in 34 adults with prediabetes found lower blood sugar
  Randomized trial202334 peoplePoints to benefit
• A 2-month berberine trial in 49 overweight adults: lower blood sugar, less fat
  Randomized trial202349 peoplePoints to benefit
• 12-week berberine trial in 409 adults with new type 2 diabetes: lower blood sugar
  Randomized trial2020409 peoplePoints to benefit
• A 3-month berberine trial in 84 adults with type 2 diabetes: lower blood sugar
  Randomized trial200884 peoplePoints to benefit
• A 3-month berberine trial in 116 adults with type 2 diabetes: lower blood sugar
  Randomized trial2008116 peoplePoints to benefit
• A 12-week berberine-blend trial in 93 adults with obesity: lower BMI and body fat
  Randomized trial202693 peoplePoints to benefit
• A 12-week berberine trial in 70 adults with fatty liver found no clear difference
  Randomized trial202470 peopleNo difference
• 3-month trial in 50 adults with obesity: berberine lowered weight, Gymnema lowered blood sugar
  Randomized trial202450 peopleMixed
• A 60-day berberine study in 12 women with polycystic ovary syndrome found lower BMI
  Trial, not randomized202112 peoplePoints to benefit
• 18-week HTD1801 trial in 100 adults with fatty liver and diabetes: less liver fat
  Randomized trial2021100 peoplePoints to benefit
• A 16-week berberine trial in 184 adults with fatty liver found less liver fat
  Randomized trial2015184 peoplePoints to benefit
• A 3-month trial in 150 women with polycystic ovary syndrome: berberine lowered insulin resistance
  Randomized trial2014150 peoplePoints to benefit
• A 6-month berberine trial in 337 adults with fatty liver: no clear fat change
  Randomized trial2026337 peopleNo difference
• One dose of berberine in mice and 15 healthy men raised insulin release
  Randomized trial202115 peoplePoints to benefit
• Plan for a 3-month trial of berberine in 240 adults with slow-onset autoimmune diabetes
  Trial plan, no results yet2022No direction

Population studies (2)

• Records study in women with polycystic ovary syndrome: berberine linked to lower weight
  Population study: followed a group2026Points to benefit
• Look-back study of 385 adults with fatty liver: berberine linked to lower weight
  Population study: followed a group2022385 peoplePoints to benefit

Animal and cell (1)

• In mice with polycystic ovary syndrome, berberine lowered fat cell size and blood sugar
  Animal study2024Points to benefit

Reviews (7)

• Review of 54 reviews: berberine improved most diabetes outcomes; evidence quality mostly very low
  Systematic review2025Points to benefit
• Pooled review of 10 trials, 811 people with fatty liver: lower BMI, insulin resistance
  Pooled review (meta-analysis)2024811 peoplePoints to benefit
• Review of 11 pooled analyses: berberine lowered blood sugar and body measures, uneven quality
  Systematic review2023Points to benefit
• Pooled review of 37 studies, 3,048 people with type 2 diabetes: lower blood sugar
  Pooled review (meta-analysis)20223,048 peoplePoints to benefit
• Pooled review of 46 studies in type 2 diabetes: lower blood sugar and BMI
  Pooled review (meta-analysis)2021Points to benefit
• Pooled review of 28 studies, 2,313 people with type 2 diabetes: lower blood sugar
  Pooled review (meta-analysis)20192,313 peoplePoints to benefit
• Pooled review of 27 studies, 2,569 people: berberine tended to lower blood sugar
  Pooled review (meta-analysis)20152,569 peoplePoints to benefit

Opinion (1)

• Review of berberine, mostly cell and animal work; people had better blood sugar handling
  Opinion or narrative review2020Points to benefit