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Animal study

In mice bred for Alzheimer-type changes, lion's mane did not clearly improve spatial memory

Rodriguez and colleagues · Behavioral sciences (Basel, Switzerland) · 2022

Original title: Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

No difference

Treated mice were less anxious in two tests. No improvements were seen in spatial memory or activities of daily living.

The study at a glance

Type of study
Animal study
Who or what was studied
Mice bred to develop Alzheimer-type brain changes
What was tested
Diet with lion's mane for 4.5 months, vs standard diet
What it measured
Several kinds of outcomes
Who has a stake
No stake declared
No competing interests declared.
Journal
Behavioral sciences (Basel, Switzerland), 2022
Source
PubMed record 35877305. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: memory and thinking

    4

    1 benefit, 3 mixed

  2. Trials in people: other measures

    0

    None among the papers we read.

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    1

    1 no difference

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does lion's mane improve memory?”

Unclear. Only four trials, with mixed results.

Confidence: very low. Based on 6 on-topic papers.

Read the full answer

Few other papers sit on the same step, so there is little to compare it with.

Other papers on the same step

None among the papers we read.

See all 6 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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