4-week trial in 137 women: red light cut eye-area wrinkle volume 31.6%, amber 29.9%

What the study found

Points to benefit

Wrinkle volume near the eyes fell 31.6% with red and 29.9% with amber light. Skin moisture and stretchiness did not improve. Quality of life scores improved.

The study at a glance

Type of study

Randomized trial

Who or what was studied

137 people · 137 women aged 40 to 65 with sun-aged facial skin

What was tested

10 sessions over 4 weeks of red (660 nm) light on one side of the face and amber (590 nm) light on the other, same dose of 3.8 J/cm2; no untreated side

What it measured

The question itself: wrinkles and skin aging

How long

4 weeks

Trial registration

REBEC-6YFCBM

Who has a stake

No disclosure in PubMed
No disclosure in PubMed.

Journal

Photobiomodulation, photomedicine, and laser surgery, 2023

Source

PubMed record 36780572. This page is based on the abstract only.

How much this study counts

• ✓Randomized: people were put into groups by chance, so the groups start out alike.
• •Medium size: 137 people.
• –Short: 4 weeks. Longer-term effects are unknown.
• ✓Measured the question itself: wrinkles and skin aging.
• •The PubMed record has no conflict-of-interest statement.
• •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

How it fits with the other research

Of the other 5 papers on the same step: 4 benefit, 1 mixed. This one found benefit. It agrees with most of them.

• Quoted in “What we found”: Red (660 nm) and amber light each cut wrinkle volume near the eyes, by 31.6% and 29.9%, in 137 women; there was no untreated comparison.
• Part of the finding “Trials without a clear fake-light group”.
• Part of the finding “No light color clearly beat another”.
• Marked as a key paper in the research timeline: Largest trial: red and amber cut eye wrinkles.
• Open item for a person: Mota 2023 abstract names registration REBEC-6YFCBM, but the record's registration field is empty.
• Open item for a person: Four of six trials (Mota 2023, Wunsch 2014, Russell 2005, Lee 2007) have no conflict-of-interest statement in PubMed.

Other papers on the same step

• 16-week trial in 60 adults: light mask improved crow's feet more than sham mask
  Randomized trial2025Points to benefit
• 4-week trial in 95 women found mixed results for red light mask on wrinkles
  Randomized trial2025Mixed
• Trial in 136 volunteers: red light gave smoother skin and more collagen than controls
  Randomized trial2014Points to benefit
• 4-week trial in 76 people: LED light cut facial wrinkles by up to 36%
  Randomized trial2007Points to benefit
• Trial without a comparison group in 31 people: 81% reported big eye-area wrinkle improvement
  Trial, not randomized2005Points to benefit

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