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Opinion or narrative review

Case report: 28 months of creatine treatment improved one patient with rare gene problem

Mejdahl Nielsen and colleagues · Molecular genetics and metabolism · 2023

Original title: X-linked creatine transporter (SLC6A8) deficiency in females: Difficult to recognize, but a potentially treatable disease.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

The new case improved clinically and brain creatine rose after 28 months of treatment. The authors say supplementation should be tested in these patients.

The study at a glance

Type of study
Opinion or narrative review
Who or what was studied
girls and women with a rare gene problem that keeps creatine out of the brain
What was tested
One new case treated 28 months with creatine, arginine and glycine, plus a review of 32 reported female cases
What it measured
Several kinds of outcomes
Who has a stake
No stake declared
One author reports speaker and consulting fees from drug firms; none make creatine supplements.
Journal
Molecular genetics and metabolism, 2023
Source
PubMed record 37708665. This page is based on the abstract only.

How much this study counts

  • –An opinion or narrative review: no new data, and no set method for choosing which studies to discuss.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

This paper is not on the ladder. It is a opinion or narrative review, and reviews and opinion pieces discuss studies that are already counted on the steps below.

↑ Stronger evidence

  1. Trials in people: memory and thinking

    5

    2 benefit, 1 mixed, 2 no difference

  2. Trials in people: other measures

    6

    5 benefit, 1 mixed

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does creatine improve memory and brain health?”

Possibly a small boost to memory.

Confidence: low. Based on 21 on-topic papers.

Read the full answer

Other opinion on this question

None among the papers we read.

See all 21 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads differed. The reviewer checked the abstract and kept the first read. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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