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Longevity supplements › Metformin and Aging › Studies

Randomized trial · measured lab tests or safety

Trial in men, 29 to 45: metformin did not clearly change biological age test

Vinicki and colleagues · GeroScience · 2025

Original title: Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome.

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What the study found

No difference

Testosterone changed the antibody sugar pattern compared with placebo. Metformin did not change the sugar patterns by the study's statistical tests.

The study at a glance

Type of study
Randomized trial
Who or what was studied
White men from Europe aged 29 to 45
What was tested
Metformin, testosterone, both, or placebo; blood antibody sugar patterns (a biological age test) tracked over time
What it measured
Lab tests or markers
Trial registration
NCT02514629
Who has a stake
Company stake
Several authors own or work for Genos Ltd, a firm that sells glycan analysis tests, including the GlycanAge test.
Journal
GeroScience, 2025
Source
PubMed record 39363095. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •The abstract does not say how many people took part.
  • –Measured lab tests or markers, which stand in for aging, frailty and death in people without diabetes. A better marker does not always mean better health.
  • –Company stake: Several authors own or work for Genos Ltd, a firm that sells glycan analysis tests, including the GlycanAge test.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related disease

    1

    1 benefit

  2. Trials in people: other measures

    3

    2 no difference, 1 harm

  3. Trials in people: lab tests or safety

    6

    2 benefit, 2 mixed, 2 no difference

    ↑ This study is the ringed dot

  4. Population studies

    8

    6 benefit, 2 no difference

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    3

    2 benefit, 1 harm

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does metformin slow aging in people without diabetes?”

Not shown in people without diabetes.

Confidence: low. Based on 26 on-topic papers.

Read the full answer

Of the other 5 papers on the same step: 2 benefit, 2 mixed, 1 no difference. This one found no difference.

Other papers on the same step

See all 26 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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