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Systematic review

Review of 6 studies in 281 people found mixed results for memory and thinking

Avgerinos and colleagues · Experimental gerontology · 2018

Original title: Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Mixed

Short-term memory and reasoning may improve with creatine. Results for long-term memory, attention and reaction time were conflicting. Young people showed no change.

The study at a glance

Type of study
Systematic review
Who or what was studied
6 studies, 281 people · healthy people, mostly young adults, some older and stressed
What was tested
Creatine by mouth compared with placebo
What it measured
The question itself: memory, thinking and brain health
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Experimental gerontology, 2018
Source
PubMed record 29704637. This page is based on the abstract only.

How much this study counts

  • •Sums up 6 studies found with a set search method, without pooling the numbers.
  • ✓Measured the question itself: memory, thinking and brain health.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

This paper is not on the ladder. It is a systematic review, and reviews and opinion pieces discuss studies that are already counted on the steps below.

↑ Stronger evidence

  1. Trials in people: memory and thinking

    5

    2 benefit, 1 mixed, 2 no difference

  2. Trials in people: other measures

    6

    5 benefit, 1 mixed

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does creatine improve memory and brain health?”

Possibly a small boost to memory.

Confidence: low. Based on 21 on-topic papers.

Read the full answer

Other reviews on this question

See all 21 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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