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Randomized trial · measured other health measures

Trial in 50 babies born early: mixed results for vitamin D and breathing illness

Golan-Tripto and colleagues · Pediatric pulmonology · 2020

Original title: The effect of vitamin D administration on vitamin D status and respiratory morbidity in late premature infants.

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What the study found

Mixed

Doubling the dose did not raise vitamin D blood level (75.5 vs 99 nmol/L at 6 months) because of poor compliance. Babies with levels under 75 nmol/L had more breathing illness; AUC 0.745 for recorded acute respiratory illness.

The study at a glance

Type of study
Randomized trial
Who or what was studied
50 people · Babies born 3 to 7 weeks early
What was tested
800 IU of vitamin D3 a day vs 400 IU a day for 1 year
What it measured
Several kinds of outcomes
Daily amount
800 IU a day
How long
52 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Pediatric pulmonology, 2020
Source
PubMed record 32757317. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • •Medium size: 50 people.
  • ✓Long: about 1 year.
  • •Measured several kinds of outcomes.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: colds, flu and chest infections

    10

    2 benefit, 8 no difference

  2. Trials in people: other measures

    5

    1 benefit, 1 mixed, 2 no difference, 1 harm

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    1

    1 no difference

  4. Population studies

    1

    1 no difference

  5. Blood levels and genes

    4

    3 benefit, 1 no difference

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does vitamin D prevent colds and infections?”

Not clearly; any effect looks small.

Confidence: low. Based on 33 on-topic papers.

Read the full answer

Of the other 4 papers on the same step: 1 benefit, 2 no difference, 1 harm. This one found mixed.

Other papers on the same step

See all 33 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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