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Population study: followed a group

Study of 30,580 Spanish adults found mixed results on wine, diet and heart events

Martínez-González and colleagues · European heart journal · 2026

Original title: Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts.

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What the study found

Mixed

In PREDIMED, good diet followers counting wine had fewer heart events (HR 0.55, 95% CI 0.36-0.83) than poor followers; not counting wine, HR was 0.84 (0.61-1.15). Analyses least open to abstainer bias, and the SUN cohort, showed no clear link.

The study at a glance

Type of study
Population study: followed a group
Who or what was studied
30,580 people · 7447 older Spanish adults at high heart risk (PREDIMED) and 23,133 younger Spanish adults (SUN)
What was tested
Good Mediterranean diet habits with or without wine (about seven or more glasses a week) vs poor habits; followed 4.8 to 22 years
What it measured
The question itself: heart disease and death
Who has a stake
Company stake
Funding includes Interprofesional del vino de España (OIVE), a Spanish wine industry group.
Journal
European heart journal, 2026
Source
PubMed record 41667089. This page is based on the abstract only.

How much this study counts

  • –Shows a link, not a cause: people chose their own habits, and other differences between them may explain the result.
  • ✓Followed people over time, so habits were recorded before the outcome happened.
  • ✓Large: 30,580 people.
  • ✓Measured the question itself: heart disease and death.
  • –Company stake: Funding includes Interprofesional del vino de España (OIVE), a Spanish wine industry group.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: heart disease

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    0

    None among the papers we read.

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    5

    3 benefit, 1 mixed, 1 harm

    ↑ This study is the ringed dot

  5. Blood levels and genes

    6

    1 mixed, 2 no difference, 3 harm

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Is moderate drinking good or bad for your heart?”

Not shown to help; may harm.

Confidence: very low. Based on 21 on-topic papers.

Read the full answer

Of the other 4 papers on the same step: 3 benefit, 1 harm. This one found mixed. It differs from most of them.

Other papers on the same step

See all 21 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 3 fields after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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