Every study we read on this question

Trials in people (10)

• 12-week trial in 120 children with cerebral palsy: longer sleep and quicker falling asleep
  Randomized trial2026120 peoplePoints to benefit
• Trial in 139 adults after hip replacement: more sleep on day 2, similar sleepiness
  Randomized trial2025139 peopleMixed
• 8-week trial in 73 people with Parkinson's: melatonin improved sleep quality and sleep time
  Randomized trial202473 peoplePoints to benefit
• 14-day trial in 128 adults after knee replacement: no clear sleep difference with melatonin
  Randomized trial2024128 peopleNo difference
• 4-week trial in 1,793 adults: melatonin and CBD capsules showed no clear difference
  Randomized trial20241,793 peopleNo difference
• 4-week trial in 97 adults: melatonin cut early waking, not other sleep measures
  Randomized trial202097 peopleMixed
• 4-week melatonin trial in 60 adults with alcohol use disorder: no clear sleep difference
  Randomized trial202060 peopleNo difference
• Trial in 13 young people with severe epilepsy: no clear difference in total sleep
  Randomized trial201813 peopleNo difference
• Trial in 334 intensive care patients on breathing machines: no clear change in delirium
  Randomized trial2025334 peopleNo difference
• One-dose trial in 64 healthy adults: melatonin shortened time to fall asleep
  Randomized trial202464 peoplePoints to benefit

Reviews (9)

• Pooled review of 32 studies in intensive care: melatonin may improve sleep and delirium
  Pooled review (meta-analysis)20253,895 peoplePoints to benefit
• Pooled review of 26 studies: melatonin sped falling asleep and lengthened sleep
  Pooled review (meta-analysis)2024Points to benefit
• Pooled review of 22 trials: prolonged-release melatonin helped adults with insomnia fall asleep faster
  Pooled review (meta-analysis)20234,875 peoplePoints to benefit
• Pooled review of 69 studies of sleep drugs: melatonin-type ones may help falling asleep
  Pooled review (meta-analysis)202317,319 peoplePoints to benefit
• Pooled review of 23 studies in adults with illnesses: melatonin improved sleep quality scores
  Pooled review (meta-analysis)2022Points to benefit
• Pooled review of 154 trials in adults with insomnia: no clear overall melatonin benefit
  Pooled review (meta-analysis)202244,089 peopleNo difference
• Pooled review of 24 studies: melatonin helped children and teens, but not clearly adults
  Pooled review (meta-analysis)2022Mixed
• Review of 15 studies in pregnancy and breastfeeding found no clear safety problem
  Systematic review2022No difference
• Pooled review of 19 studies: melatonin cut time to fall asleep by 7.06 minutes
  Pooled review (meta-analysis)20131,683 peoplePoints to benefit

Opinion (1)

• Review of melatonin for children's sleep: generally safe, but long-term evidence is lacking
  Opinion or narrative review2025Mixed