Every study we read on this question

Trials in people (4)

• 4-week trial in 42 runners: no clear gain in 3000 m time trial
  Randomized trial202542 peopleNo difference
• 8-week trial in 20 male lifters: no clear max-lift gain, more reps to failure
  Randomized trial202420 peopleMixed
• 4-month trial in middle-aged adults: muscle strength up 12%, peak power not clearly changed
  Randomized trial2022Mixed
• 4-month trial in 66 older adults: no clear walking gain, some better muscle endurance
  Randomized trial202266 peopleMixed

Animal and cell (3)

• In mice after a severe infection, urolithin A improved muscle force and muscle weight
  Animal study2025Points to benefit
• In worms, rats and mice, urolithin A extended worm lifespan and improved exercise capacity
  Animal study2016Points to benefit
• In lab-grown muscle cells from 9 donors: gene activity after urolithin A or B
  Cell study2026No direction

Reviews (2)

• Pooled review of 5 trials: urolithin A did not clearly change 6-minute walk distance
  Pooled review (meta-analysis)2026236 peopleNo difference
• Review of 5 studies in 250 people: better strength and endurance, but not function
  Systematic review2024250 peopleMixed