Digestery
Longevity supplements › Urolithin A and Muscle › Studies

Animal study

In mice after a severe infection, urolithin A improved muscle force and muscle weight

Pierre and colleagues · Journal of cachexia, sarcopenia and muscle · 2025

Original title: Sepsis Induces Long-Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

In sepsis-surviving mice, urolithin A improved muscle force (215 vs 244 mN/mm2) and muscle weight, and raised energy-making in mitochondria (81 vs 106 pmol/s/mg).

The study at a glance

Type of study
Animal study
Who or what was studied
Mice that survived a severe infection (sepsis), plus muscle data from human ICU survivors
What was tested
Urolithin A given to mice after sepsis, and to cells
What it measured
Several kinds of outcomes
Who has a stake
No stake declared
The authors declare no conflicts of interest.
Journal
Journal of cachexia, sarcopenia and muscle, 2025
Source
PubMed record 40817441. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: muscle strength and endurance

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    4

    3 mixed, 1 no difference

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    2

    2 benefit

    ↑ This study is the ringed dot

  7. Cells in a dish

    1

    1 no direction

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does urolithin A improve muscle health with age?”

Unclear: small trials, mixed results.

Confidence: very low. Based on 9 on-topic papers.

Read the full answer

Few other papers sit on the same step, so there is little to compare it with.

Other papers on the same step

See all 9 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
Not yet. Required before search engines may list this page.

Spot an error? Email a flag with a link to your source, or use the form on the question page.