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Cell study

In lab-grown muscle cells from 9 donors: gene activity after urolithin A or B

Henrotin and colleagues · Journal of cachexia, sarcopenia and muscle · 2026

Original title: Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

No direction

UA and UB changed 1918 and 339 genes. UA mainly affected energy-making and inflammation pathways. No strength or endurance test in people.

The study at a glance

Type of study
Cell study
Who or what was studied
Muscle cells grown in a dish from 9 donors aged 55 to 96
What was tested
Urolithin A or B at 5 μM for 24 hours on muscle cells; gene activity measured
What it measured
Lab tests or markers
Who has a stake
No stake declared
The authors declare no conflicts of interest.
Journal
Journal of cachexia, sarcopenia and muscle, 2026
Source
PubMed record 42773997. This page is based on the abstract only.

How much this study counts

  • –Done in cells in a lab, the earliest stage of research. Results often do not carry over to people.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: muscle strength and endurance

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    4

    3 mixed, 1 no difference

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    2

    2 benefit

  7. Cells in a dish

    1

    1 no direction

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does urolithin A improve muscle health with age?”

Unclear: small trials, mixed results.

Confidence: very low. Based on 9 on-topic papers.

Read the full answer

Other papers on the same step

None among the papers we read.

See all 9 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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