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Diet and food › Intermittent Fasting and Weight › Studies

Trial, not randomized · measured other health measures

12-week trial in 19 adults with metabolic syndrome, no comparison group, reported lower weight

Wilkinson and colleagues · Cell metabolism · 2020

Original title: Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

The title reports lower weight, blood pressure and bad blood fats after 12 weeks of 10-hour eating. The abstract gives no weight numbers and had no control group.

The study at a glance

Type of study
Trial, not randomized
Who or what was studied
19 people · adults with metabolic syndrome, most taking statins or blood pressure drugs
What was tested
eating within a 10-hour window for 12 weeks, one group with no comparison group
What it measured
Several kinds of outcomes
How long
12 weeks
Who has a stake
Company stake
One author consults for Sanofi, Novo Nordisk and others and holds Cardero stock; another earns royalties on The Circadian Code.
Journal
Cell metabolism, 2020
Source
PubMed record 31813824. This page is based on the abstract only.

How much this study counts

  • –Not randomized: the groups may differ in ways that affect the result.
  • –No comparison group: some changes might have happened anyway.
  • –Small: 19 people. Small trials can miss real effects or find chance ones.
  • •Lasted 12 weeks.
  • •Measured several kinds of outcomes.
  • –Company stake: One author consults for Sanofi, Novo Nordisk and others and holds Cardero stock; another earns royalties on The Circadian Code.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: weight loss

    9

    5 benefit, 2 mixed, 2 no difference

  2. Trials in people: other measures

    8

    4 benefit, 3 mixed, 1 no difference

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    1

    1 benefit

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does intermittent fasting help with weight loss?”

Yes, but about like calorie cutting.

Confidence: moderate. Based on 26 on-topic papers.

Read the full answer

Of the other 7 papers on the same step: 3 benefit, 3 mixed, 1 no difference. This one found benefit.

  • Counted on the ladder, but not quoted in the page’s main findings.

Other papers on the same step

See all 26 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads differed. The reviewer checked the abstract and kept the first read. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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