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Randomized trial · measured other health measures

1-month trial in adults with fibromyalgia: magnesium did not clearly change stress or sleep

Macian and colleagues · Nutrients · 2022

Original title: Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.

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What the study found

No difference

Main stress score did not differ between groups (21.8 ± 9.6 vs. 21.6 ± 10.8, p = 0.930). Pain fell more with magnesium (p = 0.029). Sleep did not differ clearly between groups.

The study at a glance

Type of study
Randomized trial
Who or what was studied
adults with fibromyalgia (a long-term pain condition)
What was tested
100 mg magnesium chloride once a day vs placebo for 1 month
What it measured
Several kinds of outcomes
Daily amount
100 mg a day
How long
4 weeks
Who has a stake
No stake declared
No competing interests declared.
Journal
Nutrients, 2022
Source
PubMed record 35631229. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •The abstract does not say how many people took part.
  • –Short: 4 weeks. Longer-term effects are unknown.
  • •Measured several kinds of outcomes.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: sleep quality and insomnia

    1

    1 benefit

  2. Trials in people: other measures

    6

    4 benefit, 2 no difference

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    3

    2 mixed, 1 no difference

  5. Blood levels and genes

    3

    2 benefit, 1 no difference

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does magnesium help you sleep?”

Not clearly; trials disagree.

Confidence: very low. Based on 16 on-topic papers.

Read the full answer

Of the other 5 papers on the same step: 4 benefit, 1 no difference. This one found no difference. It differs from most of them.

Other papers on the same step

See all 16 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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