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Systematic review

Review of 13 cell and animal studies: fisetin helped bone loss, no human data

Yamaura and colleagues · Pharmacological research · 2022

Original title: The effects of fisetin on bone and cartilage: A systematic review.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Across 13 cell and animal studies, fisetin had good effects on bone loss and, in fewer reports, on joint wear. No human data. Studies differed too much to pool.

The study at a glance

Type of study
Systematic review
Who or what was studied
13 studies · lab cell and animal models of bone loss and joint wear (osteoporosis, osteoarthritis)
What was tested
Fisetin given to cells and animals, compared with no fisetin, across 13 studies
What it measured
Several kinds of outcomes
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Pharmacological research, 2022
Source
PubMed record 36243333. This page is based on the abstract only.

How much this study counts

  • •Sums up 13 studies found with a set search method, without pooling the numbers.
  • •Measured several kinds of outcomes.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

This paper is not on the ladder. It is a systematic review, and reviews and opinion pieces discuss studies that are already counted on the steps below.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    0

    None among the papers we read.

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    5

    5 benefit

  7. Cells in a dish

    1

    1 mixed

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does fisetin slow aging?”

Not shown in people.

Confidence: very low. Based on 12 on-topic papers.

Read the full answer
  • Quoted in “What we found”: A review of 13 cell and animal studies found fisetin helped against bone loss, with fewer reports on joint wear. It included no studies in people.
  • Summed up in “What reviews found”: Checked 13 cell and animal studies of fisetin on bone and cartilage; they were too different to pool. Found benefit for bone loss and fewer, limited reports on joint wear. It included no studies in people.
  • Marked as a key paper in the research timeline: First systematic review of fisetin on bone and cartilage.

Other reviews on this question

See all 12 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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