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Longevity supplements › Fisetin and Aging › Studies

Animal study

In old mice, clearing worn-out heart cells, fisetin included, lowered one immune cell type

Rodriguez Morales and colleagues · Circulation research · 2025

Original title: Vascular Niches Are the Primary Hotspots in Cardiac Aging.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Old hearts had worn-out cells clustered around blood vessels. Clearing them with senolytics lowered one type of immune cell (Lyve1- macrophages). Fisetin effect is not given separately.

The study at a glance

Type of study
Animal study
Who or what was studied
young (3-month) and old (18-month) mice
What was tested
Old mice given dasatinib plus quercetin, or fisetin, to clear worn-out cells
What it measured
Lab tests or markers
Who has a stake
No stake declared
COI statement says none.
Journal
Circulation research, 2025
Source
PubMed record 41090219. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    0

    None among the papers we read.

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    5

    5 benefit

    ↑ This study is the ringed dot

  7. Cells in a dish

    1

    1 mixed

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does fisetin slow aging?”

Not shown in people.

Confidence: very low. Based on 12 on-topic papers.

Read the full answer

Of the other 4 papers on the same step: 4 benefit. This one found benefit. It agrees with most of them.

  • Quoted in “What we found”: In 18-month-old mice, senolytic drugs including fisetin lowered one immune cell type in the heart; the abstract gives no fisetin-only result.
  • Part of the finding “Old mouse hearts: fewer immune cells, no function data”.
  • Marked as a key paper in the research timeline: Senolytics including fisetin tested in naturally old hearts.

Other papers on the same step

See all 12 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
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