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Longevity supplements › Fisetin and Aging › Studies

Cell study

In lab-grown cells, fisetin killed worn-out mouse cells but not worn-out human skin-cancer cells

Annunziata and colleagues · Cell stress · 2023

Original title: A versatile method for the identification of senolytic compounds.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Mixed

Fisetin killed worn-out mouse embryo cells but not worn-out human melanoma cells in the new test.

The study at a glance

Type of study
Cell study
Who or what was studied
mouse and human cells in dishes
What was tested
New lab screening method; fisetin tested on worn-out cells
What it measured
Lab tests or markers
Who has a stake
Company stake
One author consulted for Ono Pharmaceutical Co., Ltd.; the record does not say what it sells.
Journal
Cell stress, 2023
Source
PubMed record 38145234. This page is based on the abstract only.

How much this study counts

  • –Done in cells in a lab, the earliest stage of research. Results often do not carry over to people.
  • –Company stake: One author consulted for Ono Pharmaceutical Co., Ltd.; the record does not say what it sells.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    0

    None among the papers we read.

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    5

    5 benefit

  7. Cells in a dish

    1

    1 mixed

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does fisetin slow aging?”

Not shown in people.

Confidence: very low. Based on 12 on-topic papers.

Read the full answer

Few other papers sit on the same step, so there is little to compare it with.

Other papers on the same step

None among the papers we read.

See all 12 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 2 fields after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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