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Diet and food › Seed Oils and the Heart › Studies

Randomized trial · measured lab tests or safety

8-week trial in 42 adults found no clear inflammation difference, cottonseed versus olive oil

Prater and colleagues · Journal of the Academy of Nutrition and Dietetics · 2024

Original title: No Observed Difference in Inflammatory and Coagulation Markers Following Diets Rich in n-6 Polyunsaturated Fat vs Monounsaturated Fat in Adults With Untreated Hypercholesterolemia: A Randomized Trial.

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What the study found

No difference

No difference between cottonseed oil and olive oil in C-reactive protein (P = 0.70), tumor necrosis factor-α (P = 0.98), interleukin-6 (P = 0.21) or other inflammation and clotting markers.

The study at a glance

Type of study
Randomized trial
Who or what was studied
42 people · adults aged 30 to 75 with high cholesterol or blood fats, not on treatment
What was tested
Meals with 30% of energy from cottonseed oil (rich in omega-6) vs olive oil, for 8 weeks
What it measured
Lab tests or markers
How long
8 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Journal of the Academy of Nutrition and Dietetics, 2024
Source
PubMed record 37619782. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • –Small: 42 people. Small trials can miss real effects or find chance ones.
  • –Short: 8 weeks. Longer-term effects are unknown.
  • –Measured lab tests or markers, which stand in for heart disease and inflammation. A better marker does not always mean better health.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: heart disease

    1

    1 harm

  2. Trials in people: other measures

    0

    None among the papers we read.

  3. Trials in people: lab tests or safety

    4

    1 benefit, 3 no difference

    ↑ This study is the ringed dot

  4. Population studies

    2

    2 mixed

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Are seed oils bad for your heart?”

Not clearly; the evidence conflicts.

Confidence: very low. Based on 13 on-topic papers.

Read the full answer

Of the other 3 papers on the same step: 1 benefit, 2 no difference. This one found no difference. It agrees with most of them.

Other papers on the same step

See all 13 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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