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Randomized trial · measured other health measures

12-month trial in 322 heart failure patients: endurance plus resistance exercise, no clear difference

Edelmann and colleagues · Nature medicine · 2025

Original title: Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial.

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What the study found

No difference

The main combined score did not differ between groups (Kendall's tau-b = -0.073, P = 0.17). Peak oxygen use rose by 1.3 ml kg-1 min-1. No difference in time to hospital stay or all-cause mortality.

The study at a glance

Type of study
Randomized trial
Who or what was studied
322 people · patients with heart failure (stiff heart), mean age 70
What was tested
12 months of endurance plus resistance exercise vs usual care
What it measured
Several kinds of outcomes
How long
52 weeks
Who has a stake
Company stake
Many authors report fees or grants from heart drug makers such as AstraZeneca, Bayer, Novartis, Pfizer; two hold shares in a trial services company.
Journal
Nature medicine, 2025
Source
PubMed record 39747684. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Large: 322 people.
  • ✓Long: about 1 year.
  • •Measured several kinds of outcomes.
  • –Company stake: Many authors report fees or grants from heart drug makers such as AstraZeneca, Bayer, Novartis, Pfizer; two hold shares in a trial services company.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: death and healthy aging

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    7 benefit, 2 no difference

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    9

    8 benefit, 1 mixed

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does strength training help you live longer?”

Linked to longer life; not proven.

Confidence: low. Based on 26 on-topic papers.

Read the full answer

Of the other 8 papers on the same step: 7 benefit, 1 no difference. This one found no difference. It differs from most of them.

Other papers on the same step

See all 26 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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