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Randomized trial · measured other health measures

12-week trial in 12 centenarians: resistance exercise improved physical performance scores

Marcos-Perez and colleagues · Journal of cachexia, sarcopenia and muscle · 2025

Original title: Resistance Exercise Intervention Restores Functional Capacity and Improves Frailty Biomarkers in Centenarians.

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What the study found

Points to benefit

The exercise group improved on the physical performance test (SPPB 5.0 after vs 2.3 before; p = 0.01) and on frailty scores (Fried 3.0 vs 3.8). Only 12 people finished.

The study at a glance

Type of study
Randomized trial
Who or what was studied
12 people · centenarians (people aged 100 or more); 19 enrolled, 12 finished
What was tested
12 weeks of resistance exercise vs no exercise (control)
What it measured
Other health or performance measures
How long
12 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Journal of cachexia, sarcopenia and muscle, 2025
Source
PubMed record 41036686. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • –Small: 12 people. Small trials can miss real effects or find chance ones.
  • •Lasted 12 weeks.
  • •Measured other health measures, not death from any cause and healthy aging itself.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: death and healthy aging

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    7 benefit, 2 no difference

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    9

    8 benefit, 1 mixed

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does strength training help you live longer?”

Linked to longer life; not proven.

Confidence: low. Based on 26 on-topic papers.

Read the full answer

Of the other 8 papers on the same step: 6 benefit, 2 no difference. This one found benefit. It agrees with most of them.

Other papers on the same step

See all 26 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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