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Randomized trial · measured the question itself

An 8-week collagen trial in 114 women aged 45 to 65 found smaller wrinkles

Proksch and colleagues · Skin pharmacology and physiology · 2014

Original title: Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Eye wrinkle volume fell in the collagen group compared with placebo after 4 and 8 weeks (p < 0.05, 20%). Skin samples showed more procollagen type I (65%) and elastin (18%).

The study at a glance

Type of study
Randomized trial
Who or what was studied
114 people · 114 women aged 45 to 65
What was tested
2.5 g a day of a branded collagen peptide (VERISOL) for 8 weeks, vs placebo
What it measured
The question itself: skin wrinkles, elasticity and hydration
Daily amount
2.5 g a day
How long
8 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Skin pharmacology and physiology, 2014
Source
PubMed record 24401291. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •Medium size: 114 people.
  • –Short: 8 weeks. Longer-term effects are unknown.
  • ✓Measured the question itself: skin wrinkles, elasticity and hydration.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: wrinkles, skin elasticity and moisture

    15

    13 benefit, 2 mixed

    ↑ This study is the ringed dot

  2. Trials in people: other measures

    1

    1 benefit

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does collagen reduce skin aging?”

Unclear; higher-quality trials found no effect.

Confidence: low. Based on 22 on-topic papers.

Read the full answer

Of the other 14 papers on the same step: 12 benefit, 2 mixed. This one found benefit. It agrees with most of them.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 2 fields after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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