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Trial, not randomized · measured the question itself

A 12-week no-placebo study of a collagen film in 22 women found shallower wrinkles

Lee and colleagues · International journal of dermatology · 2022

Original title: Anti-aging effect of an oral disintegrating collagen film: a prospective, single-arm study.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

The collagen film reduced wrinkle depth and number and raised skin elasticity and density. There was no comparison group, so changes cannot be tied to collagen.

The study at a glance

Type of study
Trial, not randomized
Who or what was studied
22 people · 22 women
What was tested
A collagen film that melts in the mouth, used daily for 12 weeks, with no placebo group
What it measured
The question itself: skin wrinkles, elasticity and hydration
How long
12 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
International journal of dermatology, 2022
Source
PubMed record 34105764. This page is based on the abstract only.

How much this study counts

  • –Not randomized: the groups may differ in ways that affect the result.
  • ✓Compared with a placebo, a dummy treatment.
  • –Small: 22 people. Small trials can miss real effects or find chance ones.
  • •Lasted 12 weeks.
  • ✓Measured the question itself: skin wrinkles, elasticity and hydration.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: wrinkles, skin elasticity and moisture

    15

    13 benefit, 2 mixed

    ↑ This study is the ringed dot

  2. Trials in people: other measures

    1

    1 benefit

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does collagen reduce skin aging?”

Unclear; higher-quality trials found no effect.

Confidence: low. Based on 22 on-topic papers.

Read the full answer

Of the other 14 papers on the same step: 12 benefit, 2 mixed. This one found benefit. It agrees with most of them.

  • Counted on the ladder, but not quoted in the page’s main findings.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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