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Randomized trial · measured the question itself

A 12-week fish collagen trial in women aged 45 to 60 found less wrinkling

Evans and colleagues · Journal of cosmetic dermatology · 2021

Original title: A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

After 12 weeks, the collagen group had a 35% drop in wrinkle score from baseline (P = .035), and 24% greater wrinkle reduction on the right face than placebo. Cheek elasticity rose in women 45-54.

The study at a glance

Type of study
Randomized trial
Who or what was studied
Women aged 45 to 60
What was tested
A hydrolyzed fish collagen (Vinh Wellness Collagen) vs placebo for 12 weeks
What it measured
The question itself: skin wrinkles, elasticity and hydration
How long
12 weeks
Who has a stake
Company stake
Funded by Vinh Hoan Corporation, which makes the tested collagen.
Journal
Journal of cosmetic dermatology, 2021
Source
PubMed record 32799362. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •The abstract does not say how many people took part.
  • •Lasted 12 weeks.
  • ✓Measured the question itself: skin wrinkles, elasticity and hydration.
  • –Company stake: Funded by Vinh Hoan Corporation, which makes the tested collagen.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: wrinkles, skin elasticity and moisture

    15

    13 benefit, 2 mixed

    ↑ This study is the ringed dot

  2. Trials in people: other measures

    1

    1 benefit

  3. Trials in people: lab tests or safety

    0

    None among the papers we read.

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does collagen reduce skin aging?”

Unclear; higher-quality trials found no effect.

Confidence: low. Based on 22 on-topic papers.

Read the full answer

Of the other 14 papers on the same step: 12 benefit, 2 mixed. This one found benefit. It agrees with most of them.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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