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Longevity supplements › NMN and Aging › Studies

Animal study

In mice, NR rejuvenated muscle stem cells and lengthened life span

Zhang and colleagues · Science (New York, N.Y.) · 2016

Original title: NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

NR rejuvenated muscle stem cells in aged mice, delayed aging of nerve and pigment stem cells, and increased mouse life span. The abstract gives no numbers.

The study at a glance

Type of study
Animal study
Who or what was studied
Aged mice and a mouse muscular dystrophy model
What was tested
NR given to mice, vs untreated
What it measured
Several kinds of outcomes
Who has a stake
No disclosure in PubMed
No COI statement in PubMed.
Journal
Science (New York, N.Y.), 2016
Source
PubMed record 27127236. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    3 benefit, 2 mixed, 4 no difference

  3. Trials in people: lab tests or safety

    7

    4 benefit, 1 mixed, 2 no difference

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    6

    5 benefit, 1 mixed

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does NMN slow aging?”

Not shown in people so far.

Confidence: very low. Based on 29 on-topic papers.

Read the full answer

Of the other 5 papers on the same step: 4 benefit, 1 mixed. This one found benefit. It agrees with most of them.

  • Quoted in “What we found”: Longer life was seen only in mice: NR increased mouse life span, and NMN raised median lifespan 8.5% in female mice only.
  • Part of the finding “Longer life and less frailty seen only in mice”.
  • Marked as a key paper in the research timeline: NR lengthened life span in mice.

Other papers on the same step

See all 29 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads differed. The reviewer checked the abstract and kept the first read. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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