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Randomized trial · measured other health measures

A 24-week NMN trial in 14 older men: no clear grip or walking change

Akasaka and colleagues · Geriatrics & gerontology international · 2023

Original title: Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study.

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What the study found

No difference

NMN was safe. Changes in grip strength and walking speed did not differ: 1.25 kg (95% confidence interval -2.31 to 4.81) and 0.033 m/s (-0.021 to 0.087) with NMN.

The study at a glance

Type of study
Randomized trial
Who or what was studied
14 people · Men aged 65 and over with diabetes and weak grip or slow walking
What was tested
NMN 250 mg a day for 24 weeks, vs placebo
What it measured
Other health or performance measures
Daily amount
250 mg a day
How long
24 weeks
Who has a stake
Company stake
Funded by Teijin Ltd; no COI statement in PubMed.
Journal
Geriatrics & gerontology international, 2023
Source
PubMed record 36443648. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • –Small: 14 people. Small trials can miss real effects or find chance ones.
  • •Lasted 24 weeks.
  • •Measured other health measures, not aging and age-related decline itself.
  • –Company stake: Funded by Teijin Ltd; no COI statement in PubMed.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    3 benefit, 2 mixed, 4 no difference

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    7

    4 benefit, 1 mixed, 2 no difference

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    6

    5 benefit, 1 mixed

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does NMN slow aging?”

Not shown in people so far.

Confidence: very low. Based on 29 on-topic papers.

Read the full answer

Of the other 8 papers on the same step: 3 benefit, 2 mixed, 3 no difference. This one found no difference.

Other papers on the same step

See all 29 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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