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Longevity supplements › NMN and Aging › Studies

Animal study

In mice, vitamin B3 protected eyes; 93% had no glaucoma at the top dose

Williams and colleagues · Science (New York, N.Y.) · 2017

Original title: Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Retinal NAD+ falls with age. Nicotinamide protected the eye. At the highest dose tested, 93% of eyes did not develop glaucoma.

The study at a glance

Type of study
Animal study
Who or what was studied
Glaucoma-prone mice as they aged
What was tested
Nicotinamide (vitamin B3) by mouth, at several doses, and gene therapy
What it measured
The question itself: aging and age-related decline
Who has a stake
No disclosure in PubMed
No COI statement in PubMed.
Journal
Science (New York, N.Y.), 2017
Source
PubMed record 28209901. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    3 benefit, 2 mixed, 4 no difference

  3. Trials in people: lab tests or safety

    7

    4 benefit, 1 mixed, 2 no difference

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    6

    5 benefit, 1 mixed

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does NMN slow aging?”

Not shown in people so far.

Confidence: very low. Based on 29 on-topic papers.

Read the full answer

Of the other 5 papers on the same step: 4 benefit, 1 mixed. This one found benefit. It agrees with most of them.

Other papers on the same step

See all 29 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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