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Longevity supplements › NMN and Aging › Studies

Animal study

In mice, long-term NMN reduced frailty in both sexes; longer life only in females

Kane and colleagues · bioRxiv : the preprint server for biology · 2024

Original title: Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Mixed

NMN reduced frailty and increased activity in both sexes, without more tumors. Median lifespan rose 8.5% in females but not males. Metabolic health improved in males but not females.

The study at a glance

Type of study
Animal study
Who or what was studied
Male and female mice treated long term
What was tested
NMN long term, vs untreated mice
What it measured
The question itself: aging and age-related decline
Who has a stake
No disclosure in PubMed
No COI statement in PubMed.
Journal
bioRxiv : the preprint server for biology, 2024
Source
PubMed record 38979132. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    3 benefit, 2 mixed, 4 no difference

  3. Trials in people: lab tests or safety

    7

    4 benefit, 1 mixed, 2 no difference

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    6

    5 benefit, 1 mixed

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does NMN slow aging?”

Not shown in people so far.

Confidence: very low. Based on 29 on-topic papers.

Read the full answer

Of the other 5 papers on the same step: 5 benefit. This one found mixed. It differs from most of them.

  • Quoted in “What we found”: Longer life was seen only in mice: NR increased mouse life span, and NMN raised median lifespan 8.5% in female mice only.
  • Part of the finding “Longer life and less frailty seen only in mice”.
  • Marked as a key paper in the research timeline: NMN extended lifespan in female mice only.
  • Open item for a person: Kane 2024 is a bioRxiv preprint; check whether a peer-reviewed version exists before relying on its lifespan result.

Other papers on the same step

See all 29 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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