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Longevity supplements › NMN and Aging › Studies

Animal study

In mice, NaR raised NAD+ in many organs and eased kidney inflammation

Song and colleagues · Cell metabolism · 2025

Original title: Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Blood NaR falls with age. In aged mice, NaR raised blood nicotinamide and NAD+ in many organs, and reduced kidney inflammation and albumin in urine.

The study at a glance

Type of study
Animal study
Who or what was studied
Mice, including aged mice and mice lacking a liver NAD+ enzyme
What was tested
Nicotinic acid riboside (NaR) by mouth in aged mice
What it measured
Lab tests or markers
Who has a stake
No stake declared
No competing interests declared.
Journal
Cell metabolism, 2025
Source
PubMed record 40315855. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    3 benefit, 2 mixed, 4 no difference

  3. Trials in people: lab tests or safety

    7

    4 benefit, 1 mixed, 2 no difference

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    6

    5 benefit, 1 mixed

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does NMN slow aging?”

Not shown in people so far.

Confidence: very low. Based on 29 on-topic papers.

Read the full answer

Of the other 5 papers on the same step: 4 benefit, 1 mixed. This one found benefit. It agrees with most of them.

  • Counted on the ladder, but not quoted in the page’s main findings.

Other papers on the same step

See all 29 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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