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Longevity supplements › NMN and Aging › Studies

Randomized trial · measured lab tests or safety

A 12-week NMN trial in 36 adults found no clear change in artery stiffness

Katayoshi and colleagues · Scientific reports · 2023

Original title: Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.

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What the study found

No difference

Serum nicotinamide was higher with NMN. Artery stiffness (pulse wave velocity) tended to fall with NMN but did not differ from placebo.

The study at a glance

Type of study
Randomized trial
Who or what was studied
36 people · Healthy middle-aged adults
What was tested
NMN 125 mg twice a day for 12 weeks, vs placebo
What it measured
Lab tests or markers
Daily amount
250 mg a day
How long
12 weeks
Who has a stake
No stake declared
No competing interests declared.
Journal
Scientific reports, 2023
Source
PubMed record 36797393. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • –Small: 36 people. Small trials can miss real effects or find chance ones.
  • •Lasted 12 weeks.
  • –Measured lab tests or markers, which stand in for aging and age-related decline. A better marker does not always mean better health.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    0

    Not done yet. This is the step that would answer the question.

  2. Trials in people: other measures

    9

    3 benefit, 2 mixed, 4 no difference

  3. Trials in people: lab tests or safety

    7

    4 benefit, 1 mixed, 2 no difference

    ↑ This study is the ringed dot

  4. Population studies

    0

    None among the papers we read.

  5. Blood levels and genes

    0

    None among the papers we read.

  6. Animals

    6

    5 benefit, 1 mixed

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does NMN slow aging?”

Not shown in people so far.

Confidence: very low. Based on 29 on-topic papers.

Read the full answer

Of the other 6 papers on the same step: 4 benefit, 1 mixed, 1 no difference. This one found no difference. It differs from most of them.

  • Counted on the ladder, but not quoted in the page’s main findings.

Other papers on the same step

See all 29 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 2 fields after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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