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Longevity supplements › Resveratrol and Aging › Studies

Animal study

In middle-aged mice on a high-calorie diet, resveratrol raised survival

Baur and colleagues · Nature · 2006

Original title: Resveratrol improves health and survival of mice on a high-calorie diet.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Resveratrol raised survival of middle-aged mice on a high-calorie diet. It improved insulin sensitivity, motor function and mitochondrial number, lowered IGF-I, and opposed the diet's effects in 144 out of 153 altered pathways.

The study at a glance

Type of study
Animal study
Who or what was studied
Middle-aged mice fed a high-calorie diet
What was tested
Resveratrol vs no resveratrol in mice on a high-calorie diet
What it measured
The question itself: aging and age-related disease
Who has a stake
Company stake
Authors declare competing financial interests; details are on the Nature website, not in PubMed.
Journal
Nature, 2006
Source
PubMed record 17086191. This page is based on the abstract only.

How much this study counts

  • –Done in animals. Results in animals often do not carry over to people.
  • –Company stake: Authors declare competing financial interests; details are on the Nature website, not in PubMed.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

    ↑ This study is the ringed dot

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Few other papers sit on the same step, so there is little to compare it with.

Other papers on the same step

None among the papers we read.

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 2 fields after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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