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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured the question itself

A 24-month trial in 125 postmenopausal women found better overall thinking with resveratrol

Thaung Zaw and colleagues · Clinical nutrition (Edinburgh, Scotland) · 2021

Original title: Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study.

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What the study found

Points to benefit

Overall thinking performance was 33% better than placebo (Cohen's d = 0.170, P = 0.005). Brain blood flow, fasting insulin and insulin resistance also improved.

The study at a glance

Type of study
Randomized trial
Who or what was studied
125 people · Postmenopausal women aged 45 to 85
What was tested
Resveratrol 75 mg twice daily vs placebo, each for 12 months, then switched (24-month crossover)
What it measured
The question itself: aging and age-related disease
Daily amount
150 mg a day
How long
104 weeks
Who has a stake
No stake declared
No conflict of interest declared.
Journal
Clinical nutrition (Edinburgh, Scotland), 2021
Source
PubMed record 32900519. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •Medium size: 125 people.
  • ✓Long: about 2 years.
  • ✓Measured the question itself: aging and age-related disease.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

    ↑ This study is the ringed dot

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 2 papers on the same step: 1 mixed, 1 no difference. This one found benefit.

  • Quoted in “What we found”: In 125 postmenopausal women taking resveratrol for 12 months versus placebo, overall thinking scores were 33% better, a small effect (Cohen's d = 0.170).
  • Part of the finding “Memory and thinking: mixed results in older adults”.
  • Marked as a key paper in the research timeline: Longest human trial, 24-month crossover: small thinking gain.
  • Open item for a person: Wong 2020 and Thaung Zaw 2021 report the same RESHAW trial; count it once when tallying trials and people.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
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