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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured other health measures

18-week trial in 129 adults with knee osteoarthritis: better balance and walking speed

Karim and colleagues · Explore (New York, N.Y.) · 2026

Original title: Improvement in postural imbalance with intake of resveratrol (polyphenolic phytoalexin) in patients of knee osteoarthritis.

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What the study found

Points to benefit

Balance, gait speed, knee range of motion and handgrip strength improved, and walking pain and WOMAC scores fell (all p < 0.05). Oxford Knee Score and resting pain did not change.

The study at a glance

Type of study
Randomized trial
Who or what was studied
129 people · Adults with knee osteoarthritis (a joint problem common in older age)
What was tested
Resveratrol 500 mg a day vs placebo for 18 weeks
What it measured
Other health or performance measures
Daily amount
500 mg a day
How long
18 weeks
Who has a stake
No stake declared
No competing interests declared.
Journal
Explore (New York, N.Y.), 2026
Source
PubMed record 41679011. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •Medium size: 129 people.
  • •Lasted 18 weeks.
  • •Measured other health measures, not aging and age-related disease itself.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 2 papers on the same step: 1 mixed, 1 harm. This one found benefit.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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