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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured lab tests or safety

6-month trial in 97 adults with type 2 diabetes: resveratrol raised antioxidant levels

García-Martínez and colleagues · International journal of molecular sciences · 2023

Original title: Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes.

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What the study found

Points to benefit

On 1000 mg/day, total antioxidant capacity and sirtuin 1 levels rose (p < 0.05). In the placebo group, lipoperoxides, isoprostanes and C-reactive protein rose (p < 0.05).

The study at a glance

Type of study
Randomized trial
Who or what was studied
97 people · Older adults with type 2 diabetes
What was tested
Resveratrol 1000 mg a day or 500 mg a day vs placebo for 6 months
What it measured
Lab tests or markers
Daily amount
1000 mg a day
How long
26 weeks
Who has a stake
No stake declared
No competing interests declared.
Journal
International journal of molecular sciences, 2023
Source
PubMed record 37108584. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •Medium size: 97 people.
  • •Lasted 26 weeks.
  • –Measured lab tests or markers, which stand in for aging and age-related disease. A better marker does not always mean better health.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

    ↑ This study is the ringed dot

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 6 papers on the same step: 3 benefit, 2 mixed, 1 no difference. This one found benefit.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
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