Digestery
Longevity supplements › Resveratrol and Aging › Studies

Blood level study

Study that followed 783 older Italians: urine resveratrol showed no clear link to death

Semba and colleagues · JAMA internal medicine · 2014

Original title: Resveratrol levels and all-cause mortality in older community-dwelling adults.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

No difference

268 (34.3%) died. Lowest-level group had a hazards ratio for death of 0.80 (95% CI, 0.54-1.17) vs highest. No link to inflammation markers, heart disease or cancer.

The study at a glance

Type of study
Blood level study
Who or what was studied
783 people · Men and women aged 65 or older in two Italian villages, followed for 9 years
What was tested
Compared people with the lowest to highest urine levels of resveratrol from diet
What it measured
The question itself: aging and age-related disease
Who has a stake
No stake declared
No conflicts declared; funded by US government health institutes.
Journal
JAMA internal medicine, 2014
Source
PubMed record 24819981. This page is based on the abstract only.

How much this study counts

  • –Links blood levels to health. A blood level can be a sign of illness rather than a cause.
  • •783 people.
  • ✓Measured the question itself: aging and age-related disease.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

    ↑ This study is the ringed dot

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Few other papers sit on the same step, so there is little to compare it with.

  • Quoted in “What we found”: Among 783 adults aged 65 or older followed for 9 years, resveratrol levels from diet were not linked to risk of death.
  • Part of the finding “Diet levels and death: no link found”.
  • Marked as a key paper in the research timeline: Diet resveratrol levels not linked to death.
  • Open item for a person: Semba 2014 is tagged Randomized Controlled Trial in PubMed but is an observational study of urine levels.

Other papers on the same step

None among the papers we read.

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads differed. The reviewer checked the abstract and kept the first read. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
Not yet. Required before search engines may list this page.

Spot an error? Email a flag with a link to your source, or use the form on the question page.