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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured lab tests or safety

6-week trial in 30 older adults found mixed results with high-dose resveratrol

Pollack and colleagues · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017

Original title: Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

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What the study found

Mixed

No change in glucose tolerance, insulin sensitivity, weight, blood pressure or blood fats. Blood vessel test improved (2.02 ± 0.2 vs 1.76 ± 0.02, p = .002). Muscle mitochondria number rose.

The study at a glance

Type of study
Randomized trial
Who or what was studied
30 people · Older adults with poor blood sugar control
What was tested
Resveratrol 2 to 3 g a day vs placebo, 6 weeks each, in a crossover
What it measured
Lab tests or markers
Daily amount
3 g a day
How long
6 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences, 2017
Source
PubMed record 28329397. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • –Small: 30 people. Small trials can miss real effects or find chance ones.
  • –Short: 6 weeks. Longer-term effects are unknown.
  • –Measured lab tests or markers, which stand in for aging and age-related disease. A better marker does not always mean better health.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

    ↑ This study is the ringed dot

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 6 papers on the same step: 4 benefit, 1 mixed, 1 no difference. This one found mixed. It differs from most of them.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
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