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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured other health measures

8-week trial in 27 older men: resveratrol blunted fitness gains from exercise

Gliemann and colleagues · The Journal of physiology · 2013

Original title: Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men.

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What the study found

Points to harm

Exercise raised maximal oxygen uptake 45% more in the placebo group than the resveratrol group (P < 0.05). Blood pressure fell only on placebo (-4.8 ± 1.7 mmHg). Resveratrol also blocked the exercise gains in cholesterol and triglycerides.

The study at a glance

Type of study
Randomized trial
Who or what was studied
27 people · Healthy, inactive men around 65 years old
What was tested
Resveratrol 250 mg a day vs placebo for 8 weeks, while doing high-intensity exercise training
What it measured
Several kinds of outcomes
Daily amount
250 mg a day
How long
8 weeks
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
The Journal of physiology, 2013
Source
PubMed record 23878368. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • –Small: 27 people. Small trials can miss real effects or find chance ones.
  • –Short: 8 weeks. Longer-term effects are unknown.
  • •Measured several kinds of outcomes.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

    ↑ This study is the ringed dot

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 2 papers on the same step: 1 benefit, 1 mixed. This one found harm.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 1 field after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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