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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured lab tests or safety

Trial in 36 adults with diabetes: single resveratrol doses raised brain blood vessel response

Wong and colleagues · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016

Original title: Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus.

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

Points to benefit

Brain blood vessel response to carbon dioxide rose vs placebo: 13.8 ± 3.5% for 75 mg (P = 0.001), 8.9 ± 3.5% for 150 mg, 13.7 ± 3.3% for 300 mg.

The study at a glance

Type of study
Randomized trial
Who or what was studied
36 people · Older adults with type 2 diabetes and no dementia, aged 49 to 78
What was tested
Single doses of resveratrol 0, 75, 150 and 300 mg, one week apart, in a crossover
What it measured
Lab tests or markers
Trial registration
ACTRN12614000891628
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016
Source
PubMed record 27105868. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • –Small: 36 people. Small trials can miss real effects or find chance ones.
  • –Measured lab tests or markers, which stand in for aging and age-related disease. A better marker does not always mean better health.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

    ↑ This study is the ringed dot

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 6 papers on the same step: 3 benefit, 2 mixed, 1 no difference. This one found benefit.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The reviewer corrected 2 fields after reading the abstract. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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