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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured the question itself

26-week trial in 60 healthy older adults found no clear change in verbal memory

Huhn and colleagues · NeuroImage · 2018

Original title: Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.

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What the study found

No difference

No clear change in verbal memory (main test). Pattern memory showed a trend to hold up on resveratrol (n.s., p = 0.07). Several blood markers, including inflammation, rose in both groups, partly more with resveratrol.

The study at a glance

Type of study
Randomized trial
Who or what was studied
60 people · Healthy adults aged 60 to 79
What was tested
Resveratrol 200 mg a day vs placebo for 26 weeks
What it measured
The question itself: aging and age-related disease
Daily amount
200 mg a day
How long
26 weeks
Trial registration
NCT02621554
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
NeuroImage, 2018
Source
PubMed record 29548848. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • •Medium size: 60 people.
  • •Lasted 26 weeks.
  • ✓Measured the question itself: aging and age-related disease.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

    ↑ This study is the ringed dot

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 2 papers on the same step: 1 benefit, 1 mixed. This one found no difference.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
Source check by a person
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