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Longevity supplements › Resveratrol and Aging › Studies

Randomized trial · measured lab tests or safety

30-day trial in 48 healthy adults: resveratrol and eating less both raised SIRT1

Gonçalinho and colleagues · Nutrients · 2023

Original title: Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol.

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What the study found

Points to benefit

Both resveratrol and calorie cutting raised circulating SIRT1 (p < 0.001) and lowered noradrenaline (resveratrol: p = 0.037). Vessel widening tests are reported only as links to SIRT1.

The study at a glance

Type of study
Randomized trial
Who or what was studied
48 people · Healthy adults aged 55 to 65
What was tested
Resveratrol supplements or eating fewer calories, for 30 days; no placebo group
What it measured
Lab tests or markers
How long
4 weeks
Who has a stake
No stake declared
No competing interests declared.
Journal
Nutrients, 2023
Source
PubMed record 37447275. This page is based on the abstract only.

How much this study counts

  • ✓Randomized: people were put into groups by chance, so the groups start out alike.
  • ✓Compared with a placebo, a dummy treatment.
  • –Small: 48 people. Small trials can miss real effects or find chance ones.
  • –Short: 4 weeks. Longer-term effects are unknown.
  • –Measured lab tests or markers, which stand in for aging and age-related disease. A better marker does not always mean better health.
  • ✓No competing interests declared.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

Each dot is one on-topic paper on this question. Steps near the top answer the question more directly.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

    ↑ This study is the ringed dot

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer

Of the other 6 papers on the same step: 3 benefit, 2 mixed, 1 no difference. This one found benefit.

Other papers on the same step

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
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