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Pooled review (meta-analysis)

Pooled review of 6 studies: resveratrol had no clear effect on older adults' memory

Sánchez-Nieto and colleagues · Nutricion hospitalaria · 2023

Original title: [Effect of resveratrol on cognitive functions in older adults: a systematic review and meta-analysis].

Under review. A person has not yet checked this summary against the paper. It is written from the PubMed abstract. Until a person checks it, search engines are asked not to list this page.

What the study found

No difference

No clear effect on delayed memory (SMD = 0.69, 95 % CI: 0.85-2.23, p = 0.38), immediate memory (SMD = 0.56, p = 0.15), working memory (SMD = -0.21, p = 0.43) or processing speed (SMD = 0.25, p = 0.55).

The study at a glance

Type of study
Pooled review (meta-analysis)
Who or what was studied
6 studies · Older adults
What was tested
Resveratrol vs comparison on memory and thinking speed, pooled from 6 studies
What it measured
The question itself: aging and age-related disease
Who has a stake
No disclosure in PubMed
No disclosure in PubMed.
Journal
Nutricion hospitalaria, 2023
Source
PubMed record 37522434. This page is based on the abstract only.

How much this study counts

  • ✓Pools the results of 6 studies.
  • •A pooled review is only as strong as the studies it pools.
  • ✓Measured the question itself: aging and age-related disease.
  • •The PubMed record has no conflict-of-interest statement.
  • •Summarized from the PubMed abstract only. The full paper may hold details the abstract leaves out.

✓ Strength– Limit• Note

These points come from fixed rules about the type of study, its size and length, what it measured, and who has a stake. Every study on Digestery gets the same rules.

Where this study sits

This paper is not on the ladder. It is a pooled review (meta-analysis), and reviews and opinion pieces discuss studies that are already counted on the steps below.

↑ Stronger evidence

  1. Trials in people: aging and age-related decline

    3

    1 benefit, 1 mixed, 1 no difference

  2. Trials in people: other measures

    3

    1 benefit, 1 mixed, 1 harm

  3. Trials in people: lab tests or safety

    7

    4 benefit, 2 mixed, 1 no difference

  4. Population studies

    1

    1 benefit

  5. Blood levels and genes

    1

    1 no difference

  6. Animals

    1

    1 benefit

↓ Weaker evidence

  • Points to benefit
  • Mixed
  • No difference
  • No direction
  • Points to harm

How it fits with the other research

The short answer to “Does resveratrol slow aging?”

Not shown in people.

Confidence: very low. Based on 22 on-topic papers.

Read the full answer
  • Quoted in “What we found”: A pooled review of six studies in older adults found no clear effect of resveratrol on delayed, immediate or working memory, or on processing speed.
  • Part of the finding “Memory and thinking: mixed results in older adults”.
  • Summed up in “What reviews found”: Pooled six studies in older adults. Found no clear effect on delayed, immediate or working memory, or processing speed (processing speed SMD = 0.25, p = 0.55, meaning no clear difference). Authors call for studies of other doses and lengths.
  • Marked as a key paper in the research timeline: Pooled memory studies in older adults: no effect.
  • Open item for a person: Sánchez-Nieto 2023 prints the delayed-memory 95% CI as 0.85-2.23, which excludes its estimate 0.69; a minus sign is likely missing.

Other reviews on this question

See all 22 studies on this question

How this page was made

Label

First read of the abstract
Claude Sonnet
Independent second read
Claude Haiku
Differences settled
The two reads agreed on every checked field. Claude Opus 5.5.
Headline
Claude Sonnet, from the checked study record. A script checked its numbers and wording.
Numbers
Checked against the abstract by a script
“How much this study counts”
Fixed rules, the same for every study
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